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Cat#：203P21
序列（三字母）：Z-Ile-Leu-aldehyde
序列（單字母）：Z-IL-aldehyde
分子式：C??H??N?O?
分子量：362.47
CAS#：161710-10-7
合成方法：Synthetic
存儲條件：-20 ± 5 °C
應用：Alzheimer´s Disease
描述：Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid β (Aβ)-production by blocking γ-secretase activity in vitro (Aβ?? IC?? = 7.9 μM; Aβ?? IC?? = 7.6 μM). Besides blocking the formation of Aβ the dipeptide aldehyde Z-IL-CHO also blocks the production of the γ-CTF (γ-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-β-precursor protein (APP).